Number of pages: 100 | Report Format: PDF | Published date: July 15, 2022
Historical Years – 2021 | Base Year – 2022 | Forecasted Years – 2023-2031
According to the deep-dive market assessment study by Growth Plus Reports, the global liquid chromatography for biopharmaceuticals market is valued at US$ 6.3 billion in 2022 and is expected to register a revenue CAGR of 5.5% to reach US$ 10.2 billion by 2030
Liquid Chromatography for Biopharmaceuticals Market Fundamentals
Liquid chromatography is a widely used technique for the analysis of biopharmaceuticals. It is a separation technique that allows the separation, identification, and quantification of different components in a sample based on their interaction with a stationary phase and a mobile phase. Liquid chromatography is used to determine the purity of biopharmaceutical products by separating the target molecule from impurities such as aggregates, fragments, variants, and host cell proteins. This information is crucial to ensure product safety and efficacy. Biopharmaceuticals often undergo post-translational modifications (PTMs), such as glycosylation, oxidation, deamidation, and phosphorylation. Liquid chromatography, combined with other techniques such as mass spectrometry, can separate and analyze different PTM forms, providing valuable information about the heterogeneity of the biopharmaceutical product.
Liquid Chromatography for Biopharmaceuticals Market Dynamics
The global liquid chromatography for biopharmaceuticals market is mainly driven by increasing pharmaceutical R&D spending, the growing importance of HPLC tests in drug approvals, and the rising application of chromatography in purifying monoclonal antibodies. Furthermore, the growing popularity of hyphenated techniques is also likely to play a pivotal role in contributing to the growth of the market globally. Monoclonal antibodies occupy a prominent share in the overall biopharmaceuticals market. The perpetually growing pipeline of biopharmaceuticals has further augmented the demand for multi-product protein characterization and high throughput methods. The advancements in analytical methodology in the past decades, improvement in sample preparation throughput, and data handling automation have added time-saving and value to the analytical and filtration processes. Multi-product or high throughput mAb characterization methods such as electrophoresis, ion exchange chromatography, and size exclusion chromatography can increase the throughput of any size exclusion column. UHPLC technology has also been successfully introduced to improve separation resolution and reduce analysis time. UHPLC uses higher pressures than traditional HPLC with reduced solvents usage and analyst time, therefore, enabling cost and time savings. New developments have also made UHPLC useful in applying large antibodies such as mAbs. Therefore, these factors will ensure improved productivity and rapid product development in the years to come and thus drive the global liquid chromatography for biopharmaceuticals market growth.
Several advancements have also been witnessed in the field of chromatography. For instance, the introduction of highly efficient columns for biopharmaceutical analysis and the advent of instrumentation for performing analysis on these columns have enabled the rapid introduction of biotherapeutics in the market. Technologies such as UHPLC have continued to deliver better separations. They are now better understood through biopharmaceutical development and are enjoying an incumbent position.
Companies in the liquid chromatography space are intensely focusing on developing new tools and solutions to improve analytical output and augment the penetration of LC technologies in drug discovery and development. For instance, the mRNA-based vaccine development area can be divided into three parts: mRNA molecular manufacturing, plasmid manufacturing, and formulation of mRNA with liquid nanoparticles. In all these three scenarios, the molecules have a metal surface affinity.
However, the high equipment cost and shortage of skilled professionals will likely restrain market revenue growth to some extent.
Liquid Chromatography for Biopharmaceuticals Market Ecosystem
The global liquid chromatography for biopharmaceuticals market is analyzed from the following perspectives: technique, type, end user, and region.
Liquid Chromatography for Biopharmaceuticals Market by Technique
Based on the techniques, the global liquid chromatography for biopharmaceuticals market is segmented into High-Pressure Liquid Chromatography (HPLC), Low-Pressure Liquid Chromatography (LPLC), Ultra-High-Pressure Liquid Chromatography (UHPLC)/Ultra-Performance Liquid Chromatography (UPLC), and Fast Protein Liquid Chromatography (FPLC).
The high-pressure liquid chromatography (HPLC) segment accounts for the highest revenue share in the global market. Due to technological developments in high-performance liquid chromatography (HPLC) techniques that have improved the dependability and robustness of liquid chromatography processes, the market is predicted to expand. For instance, the most recent HPLC systems have dual-injection systems, multidimensional capabilities, and possibilities for intermediate pressure, improving the technique's usefulness for various research applications. Important HPLC manufacturers extending their product lines for niche markets such as preparative purification, amino acid analysis, two-dimensional liquid chromatography, method development, and clinical diagnostics are also driving the market. For instance, in October 2021, Novasep launched its Hipersep Process M HPLC system intended for commercial-scale purification of oligonucleotides, peptides, insulin, and other pharmaceutically relevant molecules.
Liquid Chromatography for Biopharmaceuticals Market by Type
Based on the types, the global liquid chromatography for biopharmaceuticals market is segmented into instruments, consumables, and software & accessories.
The instruments segment accounts for the largest revenue share in the global liquid chromatography for biopharmaceuticals market. The high price of instruments contributes to this segment's dominance in the global market. End-users are increasingly choosing cutting-edge strategy tools like UPLC and MS devices. These elements are fueling the segment's notable revenue growth.
The consumables segment is projected to record a high revenue CAGR in the global liquid chromatography for biopharmaceuticals market. Advancements in the column and pump technologies are mainly considered to contribute to the high growth rate of this segment. Furthermore, the high uptake of consumables is also directly related to the rapid growth of the overall pharmaceuticals and biopharmaceuticals market due to the growing need to develop novel therapeutics to cater to the perpetually increasing prevalence of chronic diseases. Additionally, acknowledgment of chromatography as a standard testing tool for the specificity and validity of drug agents by regulatory agencies will support the growth of liquid chromatography for biopharmaceuticals, worldwide.
Liquid Chromatography for Biopharmaceuticals Market by End User
Based on the end user, the global liquid chromatography for biopharmaceuticals market is segmented into pharmaceutical companies, academics, research institutes, and contract research organizations (CROs).
The pharmaceutical companies segment accounts for the largest revenue share in the global liquid chromatography for biopharmaceuticals market. A growing emphasis on R&D-related spending helps to sustain the high demand for biopharmaceuticals. Global pharmaceutical spending has been rising steadily. For instance, according to UNESCO, global pharmaceutical R&D spending hit US$ 1.7 trillion in 2020. Numerous novel medication molecules have been released on the market due to the realization that biopharmaceuticals can treat ailments that were previously incurable. Additionally, there is an increasing need to avoid the negative effects of using some small molecule medications and invasive procedures, driving up demand for biopharmaceuticals. Therefore, it is projected that the use of liquid chromatography in pharmaceutical firms will increase favorably throughout the forecast period.
Liquid Chromatography for Biopharmaceuticals Market by Region
Geographically, the global liquid chromatography for biopharmaceuticals market has been segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.
North America accounts for the largest revenue share in the global liquid chromatography for biopharmaceuticals market. Some of the biggest businesses producing biopharmaceuticals and laboratory equipment are domiciled in this area. The main drivers of this market in the region are the rising incidence of chronic diseases in North America and rising U.S. investment in the development of biopharmaceuticals.
The rising prevalence of chronic diseases is a significant driver of the expansion of the regional biopharmaceutical market and associated research. As reported by Globocan, cancer incidence in the US in 2020 accounted at 2,281,658, and 612,390 deaths were reported in the same year. Because there are so many cancer cases in the area, there is a high need for cancer medications that work. As a result, many market players are forced to plan their strategies accordingly, which helps the market under study flourish. Eli Lilly and Company, for instance, added Dermira to its portfolio of biopharma products in 2020. Thermo Fisher Scientific made a 475-million-dollar investment in the same year with plans to expand into gene therapy, biologics, and drug development. These events indicate strong prospects for future biopharma drug development in the region and thus support the growth of global liquid chromatography in biopharmaceuticals market.
Liquid Chromatography for Biopharmaceuticals Market Competitive Landscape
The prominent players operating in the global liquid chromatography for biopharmaceuticals market are:
Liquid Chromatography for Biopharmaceuticals Market Strategic Developments
Liquid chromatography is a widely used technique for the analysis of biopharmaceuticals. It is a separation technique that allows the separation, identification, and quantification of different components in a sample based on their interaction with a stationary phase and a mobile phase.
The revenue CAGR for the liquid chromatography for biopharmaceuticals market is 5.5% during the forecast period.
Hitachi High Tech Corp, Thermo Fisher Scientific Inc., General Electric Co., PerkinElmer Inc., and Agilent Technologies Inc. are a few of the major players in the global liquid chromatography for biopharmaceuticals market.
Asia Pacific is the region with the highest growth rate in the global liquid chromatography for biopharmaceuticals market.
Liquid chromatography systems, consumables, and maintenance can be expensive, especially for advanced high-performance systems. The cost of equipment, columns, solvents, and other consumables can burden smaller biopharmaceutical companies or research laboratories.
*Insights on financial performance are subject to the availability of information in the public domain