High-performance Liquid Chromatography (HPLC) Market

Report Overview

The global high-performance liquid chromatography (HPLC) market was pegged at US$ 4.7 billion in 2021 and is expected to witness a CAGR of 4.4% during the forecast period.

Market Fundamentals

High-performance liquid chromatography (HPLC) is an analytical technique used to separate, identify, and quantify drug and drug-related impurities. HPLC is an advanced form of liquid chromatography. The HPLC system consists of a stationary phase, a mobile phase of changeable polarity, and an ultraviolet detector. In HPLC, the sample is passed through the column under high pressure (nearly 400 atm), resulting in the faster and more efficient separation of different components. HPLC can be used for various applications including qualitative and quantitative analysis, preparation of pure substances for clinical and toxicology studies as well as trace analysis. Also, it has applications in various industries such as biopharma, food and beverage, forensics, and diagnostics laboratories.

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Market Dynamics

The launch of technologically advanced systems that help in achieving highly precise and rapid results is one of the key factors boosting the growth of the HPLC market. Moreover, factors such as increasing R&D activities in the pharmaceutical companies and investments made by these companies, and the rising importance of HPLC tests in the drug approval process are anticipated to propel the market growth during the projected period. TheIngenious and effective techniques are needed to describe and quantify structural variants and alterations, monitor product stability, and show safety and efficacy in the extensive development of protein and monoclonal antibody (mAb) treatments, for which HPLC is used. The rising popularity of hyphenated analytical techniques is also responsible for pushing the market towards growth. Coupling HPLC with Mass spectrometry is a powerful analytical technique.  

The covid-19 pandemic has greatly impacted the HPLC market. In order to develop a treatment for Covid-19, many pharmaceutical companies opted for stricter drug development guidelines to avoid the side effects. This came as an opportunity for many HPLC manufacturing key players. However, the high cost of the equipment and dearth of skilled technicians is likely to hinder the market growth to a certain extent. 

Market Ecosystem

The global HPLC market has been analyzed from three perspectives: Product Type, Application, and Region. 

High-Performance Liquid Chromatography (HPLC) Market by Product Type

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The HPLC market has been segmented into instruments, consumables, and accessories. The instrument segment is further bifurcated into HPLC systems, detectors, pumps, and fraction collectors. Consumables are categorized into columns, filters, and other consumables. Instruments hold the largest share of the HPLC market. The high cost of the instruments in the HPLC system is one of the factors, due to which this segment dominates the market. Increasing use of HPLC testing in the drug approval process, technological advancements, and new product launches are some other factors fueling the growth of this segment. 

High-performance Liquid Chromatography (HPLC) Market by Application 

The HPLC market has been segmented into application areas such as pharmaceuticals and biotechnology industries, forensics, food & beverage industries, and diagnostics.  Pharmaceuticals and biotechnology companies hold a large share in the HPLC market because of the innovation and investments made in R&D activities taken by this segment. Furthermore, in the forecast period, CROs are expected to capture the HPLC market because of the increased demand due to their expertise in biologics development. Several major pharmaceutical companies are engaging with the CROs to reduce the burden on their own R&D setup. 

High-performance liquid chromatography (HPLC) Market by Region

Regionally, the global HPLC market has been segmented into North America, Europe, Asia Pacific, and the Rest of the World (RoW). North America holds the largest share of the global HPLC market. The increasing burden of chronic diseases and presence of highly skilled health professionals all over North America and growing investment in the development of biopharmaceuticals in the U.S. are the chief factors supporting this market in the region. Many technological advancements and attempts to develop an effective treatment for Covid-19, enhanced the market. Increased incidence of cancer cases in the United States, raised the demand to develop cancer drugs, thus driving the HPLC market. 

Competitive Landscape

Some of the prominent players operating in the global HPLC market include Agilent Technologies Inc., Thermo Fisher Scientific Inc., Bio-Rad Laboratories Inc., Waters Corporation, Shimadzu Corporation, PerkinElmer Inc., Hitachi High-Technologies Corporation, Merck KGaA, Tosoh Bioscence LLC, and Danaher Corporation among others.

Strategic Developments

• In June 2022. Thermo Fisher announced the production of new µPAC Neo HPLC Column. The new column delivers exceptional separation performance over a wide range of flow rates, offering the ultra-high resolution needed to extract maximum information from complex samples. As a result, laboratories will be able to identify a greater number of proteins and peptides in their proteomics experiments. 
• In March 2021, PerkinElmer announced LC 300TM HPLC/UHPLC and SimplicityChromTM CDS solution, along with its reagents and OneSource® laboratory services. This brings convenience to the customers of a single buying channel for full-LC workflow. 
• June 2020, Waters corporation introduced the Waters™ Arc™ HPLC System, a new high-performance liquid chromatography (HPLC) for routine testing in the pharmaceutical, food, academic and materials markets. A key target application is quality control laboratories performing batch release tests on small molecule pharmaceuticals.

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