Number of pages: 100 | Report Format: PDF | Published date: February 02, 2022
Historical Years – 2021 | Base Year – 2022 | Forecasted Years – 2023-2031
According to the deep-dive market assessment study by Growth Plus Reports, the global high-performance liquid chromatography market was valued at US$ 4.41 billion in 2022 and is expected to register a revenue CAGR of 5.10% to reach US$ 6.90 billion by 2031.
High-performance Liquid Chromatography Market Fundamentals
High-performance liquid chromatography (HPLC) is a sophisticated analytical tool often used in many disciplines, including chemistry, pharmacology, biotechnology, environmental sciences, and forensics. With extraordinary accuracy and sensitivity, HPLC makes it possible to separate, identify, and quantify complicated mixtures. A high-pressure pump to deliver the mobile phase at a constant flow rate, an injector to introduce the sample into the mobile phase, a column to separate the analytes, a detector to measure analyte concentration, and a data acquisition system to analyze and visualize the results are the key components of an HPLC system. The type of analytes and the particular needs of the analysis will determine the column, mobile phase, and detector to use.
Many end use sectors, including the food industry, biotechnology, pharmaceutical, and others, employ the HPLC method. HPLC is used in the pharmaceutical sector at all drug research and development phases. During the production process, it is used to subjectively and quantitatively assess the components of medications. The food sector uses HPLC to monitor and maintain quality by examining and isolating vitamins, additives, preservatives, amino acids, and proteins. Detecting and separating pollutants from food goods is another application for it.
Pharmacological analysis and quality assurance are crucially dependent on HPLC. Active pharmaceutical ingredients (APIs) and contaminants in drug formulations may be identified and measured due to this technology. HPLC procedures are used to evaluate medication purity, solubility, stability, and bioavailability to ensure the security and effectiveness of pharmaceutical goods. On the other hand, environmental analysis pollutants and contaminants in environmental samples may more easily be found and measured due to HPLC. Various substances, such as pesticides, heavy metals, organic pollutants, and endocrine disruptors, are analyzed in water, soil, and air samples using this technique. Environmental risk evaluation is made easier and more reliable with the use of HPLC.
High-performance Liquid Chromatography Market Dynamics
Major HPLC manufacturers are also driving the market by enhancing their product portfolios for niche markets, including preparative purification, amino acid analysis, two-dimensional liquid chromatography, method development, and clinical diagnostics. For instance, Novasep released their Hipersep Process M HPLC system in October 2021 with the intention of commercializing the purification of oligonucleotides, peptides, insulin, and other pharmaceutically essential compounds. Additionally, the use of HPLC in the biopharmaceutical industry is anticipated to increase because of the increasing popularity of protein-based treatments, including bispecific antibodies and antibody-drug conjugates.
Launching numerous liquid chromatography method development systems and supporting software in recent years is anticipated to simplify HPLC system usage and boost productivity. For instance, Thermo Fisher Scientific, Inc. and ChromSword worked together to introduce the Thermo Fisher Vanquish HPLC and UHPLC method development system in August 2021. Similarly, Shimadzu Corporation introduced its LabSolutions MD software for HPLC systems in April 2022 to enable the creation of analytical methods. Introducing such products is likely to boost market growth and expand the use of HPLC systems.
Several major market players have also expressed interest in developing cutting-edge HPLC-based systems for various laboratory uses, including diagnostics. For instance, Trivitron Healthcare introduced HPLC-based diagnostic solutions in June 2021, including the HbA1c analyzers for tracking thalassemia, diabetes, and hemoglobin variations. The five samples can be processed simultaneously by the fully automated NANO H5 analyzer. With a large sample loading capacity of 110 samples simultaneously, the NANO H110 is a portable, automated HPLC analyzer with a dual test mode for the HbA1c test and Hb Variant detection. During the research period, these advancements are anticipated to fuel market expansion.
As chiral compounds become more prevalent in medicines, this field is predicted to face substantial obstacles. These substances may produce more than 50 distinct peaks in HPLC impurity profiles because they can potentially contain numerous chiral centers. To manage such complex medications, more separation power from HPLC columns and the development of novel techniques are needed. Creating novel assays may be arduous and time-consuming, which is a significant obstacle to the market's expansion, given that chiral chemicals are used in more than 50% of recently created medications.
High-performance Liquid Chromatography Market Ecosystem
The global high-performance liquid chromatography market is analyzed from the following perspectives by product, application, end user, and region.
High-performance Liquid Chromatography Market by Product
Based on product, the global high-performance liquid chromatography market is segmented into instruments, consumables & accessories, and software. The consumables & accessories are further segmented into columns, filters, vials, tubes, and others.
Due to the growing dominance of integrated HPLC systems and the accessibility of cutting-edge detectors, the instruments segment held the largest revenue share of approximately 43.0% in 2022. As seen by the introduction of the new i-Series LC-2050/LC-2060 integrated HPLC systems by Shimadzu Corporation in February 2021, manufacturers in this field are concentrating on constructing systems that may offer increased productivity and specificity of applications. These systems provide minimal carryover and high-speed sample capacity for quality control applications. Additionally, detectors like the Solvere carbon selective detector from Activated Research Company, which works with both aqueous and organic solvents, are expanding the range of sample types for which HPLC procedures may be applied.
High-performance Liquid Chromatography Market by Application
Based on application, the global high-performance liquid chromatography market is segmented into clinical research applications, diagnostic applications, forensic applications, and other applications.
The clinical research applications held a revenue share of around 32% in 2022. This is due to the growing demand for clinical trial activities, biopharmaceutical research and development spike, and increased demand for high-throughput analytical techniques. The technique's benefits for clinical research include high analytical specificity, quick turnaround times, the ability to conduct multi- and mega-parametric tests, and applicability to thermolabile, polar, and high molecular weight compounds, distinguishing it as a strong alternative to other analytical techniques. These reasons are projected to increase the use of HPLC in clinical research.
High-performance Liquid Chromatography Market by End User
Based on end user, the global high-performance liquid chromatography market is segmented into pharmaceutical & biotechnology companies, academic & research institutions, and others.
Companies involved in pharmaceutical and biotechnology dominated the market in 2022, with approximately 35.0% revenue share of the market. Quality control, evaluating drug purity, characterizing drug candidates, assessing the stability of pharmaceutically active components, and many other tasks are carried out in these businesses using HPLC techniques. Due to the compatibility of HPLC with mass spectrometry, which improves the technique's selectivity and detection capabilities, the market is predicted to expand. This enhances the technique's growth prospects for biopharmaceutical applications and is predicted to accelerate market growth.
High-performance Liquid Chromatography Market by Region
Based on region, the global high-performance liquid chromatography market is segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.
Over the forecast period, North America is anticipated to hold a sizable market share. The market in the North American region is anticipated to expand rapidly due to the rising usage of highly sophisticated techniques and systems in the production of High-Performance Liquid Chromatography (HPLC) and the technical breakthroughs achieved in chromatographic research. The strong market growth in the area is mostly due to the high knowledge among research staff regarding the availability of cutting-edge chromatography studies in the industry.
The HPLC approach is employed by several government research institutions in the United States to investigate certain drug combination components or comparable components. The Determination of Carbonyl Compounds by Using High-Performance Liquid Chromatography (HPLC) was the topic of an article by the United States Environmental Protection Agency updated in May 2021 on the High-Performance Environmental Sampling and Analytical Methods (ESAM) Program. The use of HPLC methods in sample analysis standard procedures is a factor in the market's expansion in the North American region.
The market is expanding due to recent developments made by companies involved in the study and creation of innovative HPLC methods. A new range of consumables for high-performance chromatography and mass spectrometry called SureStart, for instance, was introduced by Thermo Fisher Scientific in February 2022. It has a unique assortment of caps, vials, inserts, kits, well plates, and mats. Analysts may utilize the new portfolio in any system since Thermo Scientific SureStart is interoperable with all add-ons and chromatography autosamplers. Throughout the projected period, such research and advancements in High-Performance Liquid Chromatography (HPLC) techniques are anticipated to drive market expansion.
Due to a huge patient pool and significant potential for clinical research, Asia Pacific is anticipated to develop at the fastest revenue CAGR of 5.60% throughout the projection period. Additionally, the widespread manufacture of generic drugs and biosimilars in nations like China and India offers bright prospects for the expansion of the use of the technology for quality assurance and testing. Additionally, it is projected that research applications of HPLC for the examination of conventional treatment choices, such as conventional Chinese medicines, would provide new market development opportunities.
High-performance Liquid Chromatography Competitive Landscape
Some of the prominent market players in high-performance liquid chromatography include,
High-performance Liquid Chromatography Strategic Development
High-performance liquid chromatography (HPLC) is a sophisticated analytical method that is often used in many disciplines, including chemistry, pharmacology, biotechnology, environmental sciences, and forensics.
The estimated market size of the high-performance liquid chromatography market in 2031 will be US$ 6.90 billion.
The revenue CAGR of the high-performance liquid chromatography market during the forecast period will be 5.10%
Some of the key market players in high-performance liquid chromatography include Merck KGaA, Waters Corporation, and Bio-Rad Laboratories, Inc.
The clinical research applications segment led the global high-performance liquid chromatography market.
*Insights on financial performance are subject to the availability of information in the public domain