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Whole Exome Sequencing Market

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Whole Exome Sequencing Market

Whole Exome Sequencing Market by Products & Services (Systems, Kits,), Technology (ION Semiconductor Sequencing), Application (Diagnostics, Drug Discovery), End-user (Research, Biopharmaceuticals) – Global Outlook & Forecast 2022-2030

GR - 357198 Category: Biotechnology

Number of pages: 100  |  Report Format: PDF  |  Published date: January 23, 2023

Historical Years – 2020  |  Base Year – 2021  |  Forecasted Years – 2022-2030


Whole Exome Sequencing Market Scope

Report Attribute

Details

Market Size Value in 2021

US$ 1.02 billion

Revenue Forecast in 2030

US$ 4.80 billion

CAGR

18.7%

Base Year for Estimation

2021

Forecast Period

2022-2030

Historical Year

2020

Segments Covered

Products & Services, Technology, Application, End-users, and Region

Regional Scope

North America, Europe, Asia Pacific, and the Rest of the World (RoW)

Report Overview

Based on the deep-dive market assessment study by Growth Plus Reports, the global Whole exome sequencing market was valued at US$ 1.02 billion in 2021 and is expected to register a revenue CAGR of 18.70% to reach US$ 4.80 billion by 2030.

Whole Exome Sequencing Market Fundamentals

An exome is defined as the sequence encompassing all exons of protein-coding genes and nonprotein coding elements, such as microRNA or lncRNA. Whole-exome sequencing (WES) is a popular approach for sequencing the bulk of the genome’s coding sections, which include most disease-causing mutations. The clinical uses of whole exome sequencing are not just limited to diagnosis. The technology can be used to assist in therapy for a patient based on their mutation profile. Whole exome sequencing solutions can also be used to estimate an individual’s risk of developing diseases, such as type 2 diabetes (T2D), Miller Syndrome, or Alzheimer’s disease.

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Whole Exome Sequencing Market Dynamics

The global whole exome sequencing market is an emerging industry expected to demonstrate rapid revenue growth during the forecast period. This can be majorly attributed to rising prevalence of genetic diseases and/or hereditary illnesses. For instance, whole exome sequencing is useful in the focused treatment of complicated disorders, such as autism spectrum disorder, neuropathy, epilepsy, and other hereditary diseases. The whole exome sequencing approach allows for an in-depth analysis of around 23,000 genes in the human genome in a single run using next-generation sequencing. 

Growing demand for whole exome sequencing among researchers due to growing R&D activities in genomic research positively influences the market revenue growth. Moreover, the market is being driven by rise in the demand for personalized medicines or therapies, which have gained momentum in recent years. 

Whole Exome Sequencing Market Ecosystem

The global whole exome sequencing market is analyzed from five perspectives: products & services, technology, application, end-user, and region. 

Whole Exome Sequencing Market by Products & Services

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Based on the products & services, the global whole exome sequencing market is segmented into systems, kits, and services. 

The systems segment is sub-segmented into the Hiseq series (Hiseq 2500 and 1500), ION torrent platform (ION PGM and ION proton), and Miseq. Similarly, the kits segment is sub-segmented into library preparation kits, DNA fragmentation, end repair, a-tailing & size selection kits, and target enrichments kits. Moreover, the services segment is sub-segmented into sequencing series, bioinformatics (data analysis) services, and others.

The systems segment accounts for the largest revenue share of the exome sequencing market and is expected to register notable revenue growth during the forecast period. The dominance of this segment can be attributed to increased demand for whole exome sequencing systems among healthcare practitioners due to ongoing advancements in bioinformatics visualization capabilities. Sequence analysis provides a wide range of services, such as experimental design, library construction from a wide range of samples, and downstream DNA sequencing, contributing to the segment's growth. Furthermore, the ever-increasing popularity of these systems among researchers and scientists to resolve various bioinformatic-related challenges boosts the revenue growth of this segment, further driving the market forward.

Whole Exome Sequencing Market by Technology

Based on the technology, the global whole exome sequencing market is segmented into ION semiconductor sequencing, sequencing by synthesis (SBS), and others (pyrosequencing and sequencing by ligation (SBL)). 

The sequencing by synthesis (SBS) segment dominates the market with the largest revenue shares owing to extensive utilization of the technology. Among other technologies, sequencing by synthesis, which is also known as next-generation sequencing (NGS), plays a significant role in sequencing data (code for proteins or exons). In recent years, healthcare practitioners in various economies have widely adopted this technology to analyze the potential structural abnormalities in the fetus/neonatal. SBS provides an effective sequence and can sequence hundreds to thousands of genes or gene regions simultaneously. Various advantages of sequencing by synthesis, such as higher sensitivity for the detection of low-frequency variants (1,2), lower limit of detection (4,5), wide-ranging genomic coverage, and large capacity with multiplexing, are driving demand for this technology. 

Whole Exome Sequencing Market by Application

Based on the application, the global whole exome sequencing market is segmented into diagnostics (monogenic (mendelian) disorder, monogenic diabetes, cancer diagnostics, and others), drug discovery & development, personalized medicine, animal & agricultural research, and others. 

The personalized medicine segment accounted for the largest revenue share in 2021. This can be attributed to increasing cancer cases causing a rise in demand for customized therapies. One such instance is increasing utilization of NGS (SBS) in various applications of pharmacogenomics, majorly in oncology for developing tailored drugs/therapies with high efficiency and reduced side effects. 

Whole Exome Sequencing Market by End-user

Based on the end-user, the global whole exome sequencing market is segmented into hospitals and clinics, research institutes and academics, pharmaceutical companies, diagnostic centers, and others. 

The research institutes and academics segment leads the whole exome sequencing market with the largest revenue share. Increasing R&D activities and the launch of advanced technologies are the major factors responsible for the growth of this segment. For instance, Avesthagen Limited, India's pioneer industry in systems biology genomics, launched a novel product called AVGEN Diagnostics in 2022. This product is the first fully integrated end-to-end individualized genetic testing service technology using the most recent next-generation sequencing technology and AI-powered precision analytics to power diagnostic testing services. 

Whole Exome Sequencing Market by Region

Based on the region, the global whole exome sequencing market is segmented into North America, Europe, Asia Pacific, and the Rest of the World. 

North America dominates the global market in terms of revenue share. Rising prevalence of chronic and genetic illnesses, increasing need for personalized treatment, growing usage of whole exome sequencing technology for the development of improved diagnostics, and increase in genomic R&D activities are driving revenue growth in the North America whole exome sequencing market. Increasing government support for cancer research and presence of significant players in the region are also driving revenue growth. 

The market in Asia Pacific is expected to register significant growth during the forecast period owing to increasing prevalence of chronic and/or genetic diseases and technological advancements. Additionally, rapid development of the Asia Pacific market can be linked to increasing per capita income and government efforts to enhance overall healthcare quality.

Whole Exome Sequencing Market Competitive Landscape

The prominent players operating in the global whole exome sequencing market are: 

Whole Exome Sequencing Market Strategic Developments

  • In Oct. 2020, QIAGEN launched QIAseq Human Exome TR Insights, a novel product that combines high-performance chemistry with sophisticated bioinformatics to the sequence. This research solution enables the creation of next-generation sequencing exome libraries, robust sequence data processing, and industry-leading variant interpretation. It offers significant benefits over market-leading devices as it enhances the levels of sequence coverage and offers a quicker process.

Frequently Asked Questions About This Report

The sequencing by the synthesis (SBS) segment dominates the global whole exome sequencing market with the largest revenue share in 2021.

The global whole exome sequencing market is expected to register a revenue CAGR of 18.7% during the forecast period.

Asia Pacific is projected to be the fastest-growing regional market for whole exome sequencing.

Illumina Inc., Eurofins Genomics Inc., Thermo Fisher Scientific Inc., Agilent Technologies, Macrogen Inc., and Roche NimbleGen Inc. are among the key companies operating in the global market.

The expected market size of the whole exome sequencing market is US$ 4,808.94 million in 2030.

Table of Content

  1. INTRODUCTION
    1. Market Ecosystem 
    2. Timeline Under Consideration
      1. Historical Years – 2020
      2. Base Year – 2021
      3. Forecast Years – 2022 to 2030
    3. Currency Used in the Report
  2. RESEARCH METHODOLOGY 
    1. Research Approach
    2. Data Collection Methodology
    3. Data Sources
      1. Secondary Sources 
      2. Primary Sources 
    4. Market Estimation Approach
      1. Bottom Up 
      2. Top Down 
    5. Market Forecasting Model
    6. Limitations and Assumptions       
  3. PREMIUM INSIGHTS
    1. Current Market Trends (COVID-19 Perspective)
    2. Key Players & Competitive Positioning (2021)
  4. MARKET DYNAMICS
    1. Drivers
    2. Restraints
    3. Opportunities
  5. GLOBAL WHOLE EXOME SEQUENCING MARKET- ANALYSIS & FORECAST, BY PRODUCTS & SERVICES
    1. Systems
      1. Hiseq Series (Hiseq 2500 and 1500)
      2. ION Torrent Platform (ION PGM and ION Proton)
      3. Miseq
    2. Kits
      1. Library Preparation Kits
      2. DNA Fragmentation, End Repair, A-Tailing & Size Selection Kits 
      3. Target Enrichments Kits
    3. Services
      1. Sequencing Series
      2. Bioinformatics (Data Analysis) Services
      3. Others
  6. GLOBAL WHOLE EXOME SEQUENCING MARKET- ANALYSIS & FORECAST, BY TECHNOLOGY
    1. ION Semiconductor Sequencing
    2. Sequencing By Synthesis (SBS)
    3. Others (Pyrosequencing, Sequencing By Ligation (SBL))
  7. GLOBAL WHOLE EXOME SEQUENCING MARKET- ANALYSIS & FORECAST, BY APPLICATION
    1. Diagnostics 
      1. Monogenic (Mendelian) Disorder
      2. Monogenic Diabetes
      3. Cancer Diagnostics
      4. Others
    2. Drug Discovery & Development
    3. Personalized Medicine
    4. Animal & Agricultural Research
    5. Others
  8. GLOBAL WHOLE EXOME SEQUENCING MARKET- ANALYSIS & FORECAST, BY END-USER
    1. Research Centers & Academics
    2. Biopharmaceuticals & Pharmaceuticals Companies
    3. Hospitals & Clinics
    4. Others
  9. GLOBAL WHOLE EXOME SEQUENCING MARKET- ANALYSIS & FORECAST, BY REGION
    1. North America Whole Exome Sequencing Market
      1. North America Whole Exome Sequencing Market, by Products & Services
      2. North America Whole Exome Sequencing Market, by Technology
      3. North America Whole Exome Sequencing Market, by Application
      4. North America Whole Exome Sequencing Market, by End-user
      5. North America Whole Exome Sequencing Market, by Country
        1. U.S.
          1. U.S. Whole Exome Sequencing Market, by Products & Services
          2. U.S. Whole Exome Sequencing Market, by Technology
          3. U.S. Whole Exome Sequencing Market, by Application
          4. U.S. Whole Exome Sequencing Market, by End-user
        2. Canada
          1. Canada Whole Exome Sequencing Market, by Products & Services
          2. Canada Whole Exome Sequencing Market, by Technology
          3. Canada Whole Exome Sequencing Market, by Application
          4. Canada Whole Exome Sequencing Market, by End-user
    2. Europe Whole Exome Sequencing Market
      1. Europe Whole Exome Sequencing Market, by Products & Services
      2. Europe Whole Exome Sequencing Market, by Technology
      3. Europe Whole Exome Sequencing Market, by Application
      4. Europe Whole Exome Sequencing Market, by End-user
      5. Europe Whole Exome Sequencing Market, by Country/Region
        1. Germany
          1. Germany Whole Exome Sequencing Market, by Products & Services
          2. Germany Whole Exome Sequencing Market, by Technology
          3. Germany Whole Exome Sequencing Market, by Application
          4. Germany Whole Exome Sequencing Market, by End-user
        2. U.K.
          1. U.K. Whole Exome Sequencing Market, by Products & Services
          2. U.K. Whole Exome Sequencing Market, by Technology
          3. U.K. Whole Exome Sequencing Market, by Application
          4. U.K. Whole Exome Sequencing Market, by End-user
        3. France
          1. France Whole Exome Sequencing Market, by Products & Services
          2. France Whole Exome Sequencing Market, by Technology
          3. France Whole Exome Sequencing Market, by Application
          4. France Whole Exome Sequencing Market, by End-user
        4. Spain
          1. Spain Whole Exome Sequencing Market, by Products & Services
          2. Spain Whole Exome Sequencing Market, by Technology
          3. Spain Whole Exome Sequencing Market, by Application
          4. Spain Whole Exome Sequencing Market, by End-user
        5. Italy
          1. Italy Whole Exome Sequencing Market, by Products & Services
          2. Italy Whole Exome Sequencing Market, by Technology
          3. Italy Whole Exome Sequencing Market, by Application
          4. Italy Whole Exome Sequencing Market, by End-user
        6. Rest of Europe
          1. Rest of Europe Whole Exome Sequencing Market, by Products & Services
          2. Rest of Europe Whole Exome Sequencing Market, by Technology
          3. Rest of Europe Whole Exome Sequencing Market, by Application
          4. Rest of Europe Whole Exome Sequencing Market, by End-user
    3. Asia Pacific Whole Exome Sequencing Market
      1. Asia Pacific Whole Exome Sequencing Market, by Products & Services
      2. Asia Pacific Whole Exome Sequencing Market, by Technology
      3. Asia Pacific Whole Exome Sequencing Market, by Application
      4. Asia Pacific Whole Exome Sequencing Market, by End-user
      5. Asia Pacific Whole Exome Sequencing Market, by Country/Region
        1. China
          1. China Whole Exome Sequencing Market, by Products & Services
          2. China Whole Exome Sequencing Market, by Technology
          3. China Whole Exome Sequencing Market, by Application
          4. China Whole Exome Sequencing Market, by End-user
        2. Japan
          1. Japan Whole Exome Sequencing Market, by Products & Services
          2. Japan Whole Exome Sequencing Market, by Technology
          3. Japan Whole Exome Sequencing Market, by Application
          4. Japan Whole Exome Sequencing Market, by End-user
        3. India
          1. India Whole Exome Sequencing Market, by Products & Services
          2. India Whole Exome Sequencing Market, by Technology
          3. India Whole Exome Sequencing Market, by Application
          4. India Whole Exome Sequencing Market, by End-user
        4. South Korea
          1. South Korea Whole Exome Sequencing Market, by Products & Services
          2. South Korea Whole Exome Sequencing Market, by Technology
          3. South Korea Whole Exome Sequencing Market, by Application
          4. South Korea Whole Exome Sequencing Market, by End-user
        5. Australia
          1. Australia Whole Exome Sequencing Market, by Products & Services
          2. Australia Whole Exome Sequencing Market, by Technology
          3. Australia Whole Exome Sequencing Market, by Application
          4. Australia Whole Exome Sequencing Market, by End-user
        6. Rest of Asia Pacific 
          1. Rest of Asia Pacific Whole Exome Sequencing Market, by Products & Services
          2. Rest of Asia Pacific Whole Exome Sequencing Market, by Technology
          3. Rest of Asia Pacific Whole Exome Sequencing Market, by Application
          4. Rest of Asia Pacific Whole Exome Sequencing Market, by End-user
    4. Rest of the World Whole Exome Sequencing Market
      1. Rest of the World Whole Exome Sequencing Market, by Product   
      2. Rest of the World Whole Exome Sequencing Market, by Application
      3. Rest of the World Whole Exome Sequencing Market, by Tissue Type
      4. Rest of the World Whole Exome Sequencing Market, by Region
        1. Latin America
          1. Latin America Whole Exome Sequencing Market, by Product   
          2. Latin America Whole Exome Sequencing Market, by Application
          3. Latin America Whole Exome Sequencing Market, by Tissue Type
        2. Middle East & Africa
          1. Middle America & Africa Whole Exome Sequencing Market, by Product 
          2. Middle America & Africa Whole Exome Sequencing Market, by Application
          3. Middle America & Africa Whole Exome Sequencing Market, by Tissue Type
  10. COMPANY PROFILES         
    1. Illumina Inc.
      1. Business Snapshot 
      2. Product Offered
      3. Financial Details
      4. Strategic Development
    2. Eurofins Genomics Inc.
    3. Thermo Fisher Scientific Inc.
    4. Agilent Technologies
    5. Macrogen Inc.
    6. Roche NimbleGen Inc.
    7. Ambry Genetics
    8. Genewiz Inc. (Azenta Life Science)
    9. Knome Inc.
    10. Beijing Genomics Institute (BGI)
    11. Sengenics
    12. Ambry Genetics

*Insights on financial performance are subject to the availability of information in the public domain


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