Single-Cell Analysis Market
Number of pages: 100 | Report Format: PDF | Published date: March 16, 2023
Historical Years – 2021 | Base Year – 2022 | Forecasted Years – 2023-2031
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Report Attribute |
Details |
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Market Size Value in 2022 |
US$ 3.96 billion |
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Revenue Forecast in 2031 |
US$ 16.66 billion |
|
CAGR |
17.3% |
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Base Year for Estimation |
2022 |
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Forecast Period |
2023-2031 |
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Historical Year |
2021 |
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Segments Covered |
Product, Application, End User, and Region |
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Regional Scope |
North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa |
According to the deep-dive market assessment study by Growth Plus Reports, the global single-cell analysis market was valued at US$ 3.96 billion in 2022 and is expected to register a revenue CAGR of 17.3% to reach US$ 16.66 billion by 2031.
Single-cell Analysis Market Fundamentals
Single-cell analysis (SCA) studies genomes, transcriptomics, proteomics, metabolomics, and cell-cell interactions at the single-cell level in cellular biology. SCA was first proposed in the 1970s. Before the discovery of heterogeneity, SCA primarily referred to examining or manipulating a single cell in a large population of cells under specific conditions using an optical or electronic microscope. The cells may appear visually and genetically identical, but they are heterogeneous, composed of individual cells that differ greatly. These disparities can significantly impact the health and function of the entire population. The SCA allows researchers to investigate cell-to-cell variation within a cell population (organ, tissue, and cell culture).
To study diseases and develop therapies, it is necessary to conduct single-cell investigations into stem cell differentiation, cancer, and physiological processes in both embryos and adults. Several SCA approaches necessitate cell isolation. Dielectrophoretic (DEP) digital sorting, enzymatic digestion, FACS, hydrodynamic traps, laser capture microdissection, manual picking, microfluidics, micromanipulation, serial dilution, and Raman tweezers are presently employed for single-cell separation. Manual single-cell picking is a technique in which cells in suspension are examined under a microscope and individually selected with a micropipette. Raman tweezers is a technology that combines Raman spectroscopy with optical tweezers, which trap and manipulate cells using a laser beam.
The DEP digital sorting method traps single cells in DEP cages using a semiconductor-controlled array of electrodes in a microfluidic chip. The combination of fluorescent markers and image analysis ensures cell identification. The semiconductor-controlled motion of DEP cages in the flow cell ensures precision distribution.
Hydrodynamic-based microfluidic biochip development has accelerated in recent years. This technique traps cells or particles in a specific region for SCA without needing external force fields, such as optical, electrical, magnetic, or acoustic.
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Single-cell Analysis Market Dynamics
Cancer is one of the most common causes of death globally. The disease has grown significantly in recent years and is anticipated to expand substantially over the projection period. According to the World Health Organization, cancer is a primary cause of death worldwide, accounting for approximately 10 million deaths in 2020, or nearly one in every six deaths. Every year, around 400 000 youngsters are diagnosed with cancer. The most common cancers differ by country. Hence, the rising global prevalence of cancer raises the diagnosis rate and the demand for better diagnostics, propelling the market. Furthermore, according to the International Institute for Research on Cancer, the global cancer burden will rise to 27.5 million new cancer cases and 16.3 million deaths by 2040. Circulating tumor cells are increasingly attracting therapeutic attention since they may allow for monitoring disease development and treatment adjustments. Single-cell sequencing has identified diagnostic and prognostic biomarkers.
SCA in clinical diagnostics is projected to standardize and automate workflows with significant information for real-time cancer monitoring and, eventually, novel therapeutic options for the benefit of patients. This feature is expected to result in more efficient and accurate analysis. As a result, growing investments in cancer research are expected to be one of the primary driving factors for the market throughout the forecast period.
Single-cell Analysis Market Ecosystem
The global single-cell analysis market has been analyzed from four perspectives: product, application, end-user, and region.
Single-Cell Analysis Market by Product
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Based on product, the global single-cell analysis market has been segmented into consumables and instruments. The instruments segment is further sub-segmented into microscopes, hemocytometers, flow cytometers, next-generation sequencing, PCR systems, high-content screening system, cell microarrays, single live cell imaging, automated cell counters, and others. Moreover, the consumables segment is sub-segmented into reagents, assay kits, and others.
The consumables segment is expected to dominate the market during the forecast period due to the simplicity of use of isolation products, widespread acceptance of cell sorting beads, frequent purchases of buffers and reagents, and a rise in the demand for test kits. The segment is growing due to an increase in the prevalence of target diseases and the ongoing requirement for consumables needed for assays during scientific operations. Furthermore, the widespread usage of consumables, such as reagents, in SCA tests produces an ongoing high demand for these items. These reagents come in various forms, such as probes, cellular markers, multicolor cocktails, and even phenotyping agents. Scientific entities' active operations have resulted in the widespread adoption and procurement of reagents, resulting in revenue growth in the global market.
Single-Cell Analysis Market by Application
The global single-cell analysis market has been segmented based on application into cancer, immunology, neurology, stem cell, non-invasive prenatal diagnosis, in-vitro fertilization, and others.
The cancer segment dominates the market with the largest revenue share. SCA is useful in the diagnosis of cancer cells. These techniques simplify identifying genetic variation via cell growth circumstances, mutation rates, and cell kinds. According to the American Cancer Society, cancer is the second leading cause of mortality in the United States, trailing only heart disease. According to cancer statistics, 1.9 million new cancer cases will be projected in the United States in 2022. Hence, the rising prevalence of cancer, as well as the never-ending research and development in this field, are expected to have a positive impact on market revenue growth.
A high rate of cancer research is being conducted globally, and the cellular, metabolic, and genetic study and evaluation of tumor cells play an important role in understanding various cancers. This leads to the development of effective diagnostics, therapeutics, and treatment options for cancer. Thus, the usage of SCA in research applications is expected to grow significantly.
Immunological tests contribute to the early detection of therapeutic problems, such as various cancer and hematology-based indications, enhancing treatment efficiency. According to an article published in the Journal of Immunology Research in 2020, single-cell RNA sequencing and analysis aid in studying the immune response to diverse infections, which can lead to the development of efficient vaccinations against the causative organism. Furthermore, the invasion of single-cell metabolic activities is raising the acceptance of its analytical techniques, pushing the expansion of the market.
Single-Cell Analysis Market by End-user
Based on end-user, the global single-cell analysis market has been segmented into academic and research laboratories, biotechnology and pharmaceutical companies, hospitals and diagnostic laboratories, and others.
The academic and research laboratories segment is expected to dominate the market during the forecast period due to the increasing usage of SCA techniques in research. The large number of ongoing scientific research at numerous universities that use SCA methodologies pushed for its implementation in 2021. Another significant element boosting the industry is the development of spatial genomics, which accelerates SCA in research operations. Furthermore, the industry is driven by developing new tools to address research limitations. For example, in June 2022, researchers at Stony Brook University in New York produced a new biomedical research tool, single-cell cyclic multiplex in situ tagging (CycMIST) technology. This technology allows scientists to evaluate functioning proteins in a single cell, which helps in the diagnostic and discovery sectors.
Single-Cell Analysis Market by Region
The global single-cell analysis market has been segmented based on region into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.
The North America region is likely to dominate the market during the forecast period due to the high prevalence of cancer, the increase in the need for stem cell research, initiatives for the early detection of chronic diseases, and the rise in awareness about commercially available cancer diagnostics and precision medicine. Cancer and immunology are two areas of inquiry gaining popularity among scientific communities. Amgen cooperated with Generate Biomedicines in January 2022 to find and develop protein therapies for five targets across many therapeutic areas and different modalities, with an initial expenditure of US$ 1.9 billion or more.
Over the forecast period, Asia Pacific is expected to have the highest revenue CAGR. In recent years, the burgeoning medical industry, fast-rising healthcare systems, and an aging population have fueled the demand for cutting-edge diagnostic technologies in Asia Pacific's emerging nations. This region's concentrated efforts and outsourcing have resulted in substantial growth.
Single-cell Analysis Market Competitive Landscape
As genetic illnesses become more common, there is a greater need for early detection and improved therapies. This has given valuable chances for new players to capitalize on the unexplored potential. These rising enterprises have concentrated on producing creative and technologically advanced products to meet consumer demand.
The prominent players in the global single-cell analysis market include:
Single-cell Analysis Market Strategic Developments
Single-cell analysis, or SCA, studies genomes, transcriptomics, proteomics, metabolomics, and cell-cell interactions at the single-cell level in cellular biology. SCA was first proposed in the 1970s. Before the discovery of heterogeneity, SCA primarily referred to examining or manipulating a single cell in a large population of cells under specific conditions using an optical or electronic microscope.
The cancer application segment leads the global single-cell analysis market.
The single-cell analysis market is expected to reach 16.66 billion by 2031.
The single-cell analysis market is expected to register a revenue CAGR of 17.8% during the forecast period.
Some prominent players in the global single-cell analysis market include Thermo Fisher Scientific, Inc., QIAGEN NV, and Agilent Technologies Inc.
*Insights on financial performance are subject to the availability of information in the public domain