Number of pages: 100 | Report Format: PDF | Published date: 02 March, 2023
Historical Years – 2021 | Base Year – 2022 | Forecasted Years – 2023-2031
Report Attribute |
Details |
Market size value in 2022 |
US$ 4.94 billion |
Revenue forecast in 2031 |
US$ 14.19 billion |
Growth Rate |
CAGR of 12.4% from 2023 to 2031 |
Base year for estimation |
2022 |
Forecast Period |
2023-2031 |
Historical Year |
2021 |
Segments covered |
Product, Application, End-user, and Region |
Regional scope |
North America, Europe, Asia Pacific, and the Rest of the World (ROW) |
According to the deep-dive market assessment study by Growth Plus Reports, the global oligonucleotide synthesis market was valued at US$ 4.94 billion in 2022 and is expected to register a revenue CAGR of 12.4% to reach US$ 14.19 billion by 2031.
Market Fundamentals
Oligonucleotides are single or double stranded nucleic acid segments that are linked together to form single chain biological polymers. Oligonucleotides can be synthesized enzymatically through the cleavage of larger biomolecules or chemically targeted synthesis. In the latter scenario, nucleoside phosphoramidites, a crucial monomeric component of oligonucleotides, are created through the chemical process known as organonucleotide synthesis. Nucleoside phosphoramidites themselves are derivatives of natural or synthetic nucleosides.
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Market Dynamics
The rising advancement in genomics sequencing, such as NGS technology, has helped to lower the overall price of sequencing, which is one of the major driving factors of the global oligonucleotide synthesis market. Moreover, the increased government initiatives to support genome sequencing projects and change the regulatory environment around genetic testing are also propelling the global market growth. There is a rise in the demand for personalized gene sequences to determine the best treatment for patients. Similarly, there is a rise in the use of oligonucleotides in therapies for different chronic diseases, including cancer, infection, and rare diseases, boosting the growth of the global market. Additionally, the rise in the application of oligonucleotides in molecular diagnostics with fewer side effects of the oligonucleotide products increases the demand for oligonucleotide synthesis. The major companies increasing their investment in research and development and the rising number of pipeline drugs are also pivotal in the growth of the global oligonucleotide synthesis market. However, the high cost of oligonucleotide synthesis is the major restriction of the worldwide market. Moreover, a lack of skilled professionals and researchers in developing countries is also hindering the growth of the global market.
Market Ecosystem
The global oligonucleotide synthesis market has been analyzed from four perspectives: Product, Application, End-user, and Region.
Oligonucleotide Synthesis Market by Product
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Based on product type, the global oligonucleotide synthesis market is segmented into oligonucleotides, equipment/synthesizer, reagents, and services.
The oligonucleotides segment dominates the global oligonucleotide synthesis market, with the largest market revenue share in 2022. The oligonucleotides segment is further sub-segmented into product and nucleic acid types. The large share of oligonucleotides can be attributed to the rising application of oligonucleotides in research, disease diagnosis, and therapeutics. Moreover, oligonucleotides are used as primers in gene expression and disease processes, pivotal in segment growth. The increase in research and development in molecular biology and synthetic biology, where oligonucleotides are vastly used, is thus increasing the demand for oligonucleotides. The rising use of oligonucleotides in genetic testing to forensic research is also anticipated to propel the segment growth.
Oligonucleotide Synthesis Market by Application
Based on application, the global oligonucleotide synthesis market is segmented into PCR assays and panels, sequencing, PCR primers, DNA microarrays, fluorescence in situ hybridization (FISH), antisense oligonucleotides, and other applications.
The PCR primers segment holds the largest market revenue share of the global oligonucleotide synthesis market in 2022. The dominating share of the PCR primers segment can largely be attributed to the increased application of PCR in drug development. Oligonucleotides are the most commonly used primer in a PCR. Moreover, the research on gene expression and disease processes has been transformed by using oligonucleotides as primers which propel the segment growth. In molecular biology, PCR has also been employed to help researchers clone and sequence genes to find mutations, increasing the demand for PCR primers. Additionally, the rise in the research on oligonucleotide-based therapeutics, including antisense therapeutics, DNA vaccines, and anti-viral agents, is also boosting segment growth.
Oligonucleotide Synthesis Market by End-user
Based on end-users, the global oligonucleotide synthesis market is segmented into pharmaceutical-biotechnology companies, academic research institutes, diagnostic laboratories.
The pharmaceutical-biotechnology companies segment leads the global oligonucleotide synthesis market with the largest market revenue share in 2022. The pharma and biotech companies are focusing on developing novel drugs; thus, there is a rise in the utilization of oligonucleotides. Moreover, oligonucleotides provide an efficient drug administration route and effective treatment mode, boosting the market growth. Additionally, the use of oligonucleotides is reducing the overall price of the drug development procedure, increasing the demand for oligonucleotides in the pharma and biotech sectors.
Oligonucleotide Synthesis Market by Region
Based on region, the global oligonucleotide synthesis market has been segmented into North America, Europe, Asia Pacific, and the Rest of the World.
North America dominated the global oligonucleotide synthesis market in 2022, followed by Europe. Asia Pacific is the fastest-growing regional market. The rise in the overall expenditure for regional research and development is boosting regional growth. The presence of the top manufacturers and research institutes in the region also propels regional growth. Additionally, the government organizations in the region are taking the initiative to promote R&D for the treatment of genetic diseases is also anticipated to fuel regional growth.
The demand for oligonucleotide synthesis in Asia is high due to the increasing number of research and development activities in the pharmaceutical and biotechnology industries. Oligonucleotide synthesis is used to develop new drugs, diagnostics, and therapeutics. The growing demand for personalized medicine and gene therapy is also driving the growth of the market. In addition, the increasing prevalence of diseases such as cancer, cardiovascular diseases, and neurological disorders is also driving the demand for oligonucleotide synthesis in the Asia Pacific region.
Moreover, the increasing number of clinical trials for oligonucleotide synthesis is also driving the demand for the process in the region. The increasing number of collaborations between key players is also driving the demand for oligonucleotide synthesis in the Asia Pacific region. For instance, in 2020, Bio-Synthesis Inc. and DNA2.0 Inc. announced a collaboration to develop a new platform for oligonucleotide synthesis. The collaboration is expected to reduce the cost of oligonucleotide synthesis. Furthermore, the increasing investment in the healthcare sector is also driving the demand for oligonucleotide synthesis in the region.
Governments in the Asia Pacific region are investing heavily in the healthcare sector to improve the quality of healthcare services. This is expected to create opportunities for the development of new drugs and diagnostics, which in turn is expected to drive the demand for oligonucleotide synthesis in the region. In addition, the increasing number of mergers and acquisitions between key players is also driving the demand for oligonucleotide synthesis in the region. For instance, in 2020, Eurofins Genomics acquired ATDBio Ltd. The acquisition is expected to strengthen Eurofins Genomics’ position in the oligonucleotide synthesis market.
The increasing awareness about the applications of oligonucleotide synthesis is also driving the demand for the process in the region. For instance, oligonucleotide synthesis is used in the development of vaccines for the treatment of various diseases. This is expected to create opportunities for the development of new vaccines, which in turn is expected to drive the demand for oligonucleotide synthesis in the region. The increasing demand for oligonucleotide synthesis in the Asia Pacific region is expected to create lucrative opportunities for the market. Key players in the market are focusing on developing innovative solutions for oligonucleotide synthesis. This is expected to fuel the growth of the market in the region.
Competitive Landscape
Some prominent players operating in the oligonucleotide synthesis market are:
Strategic Developments
The global oligonucleotide synthesis market is estimated to reach US$ 14.19 billion in 2031.
The key competitors in the global oligonucleotide synthesis market are Thermo Fisher Scientific Inc., Merck KGaA, GE Healthcare, Agilent Technologies, Eurofins Scientific SE, Integrated DNA Technologies Inc. (Part of Danaher Corporation), Eurogentec S.A., GeneDesign Inc., LGC Biosearch Technologies, Bio-synthesis Inc., TriLink BioTechnologies LLC, and BioAutomation among others.
Oligonucleotides, or oligos, are single or double stranded nucleic acid segments linked together to form single chain biological polymers. Oligonucleotides can be synthesized enzymatically though the cleavage of larger biomolecules or through chemically targeted synthesis.
The oligonucleotides segment dominates the global market with the largest market share of the global market.
The major market players are collaborating to develop novel products related to oligonucleotides.
*Insights on financial performance are subject to the availability of information in the public domain
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