Human Liver Model Market
Number of pages: 100 | Report Format: PDF | Published date: 10 February, 2023
Historical Years – 2020 | Base Year – 2021 | Forecasted Years – 2022-2030
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Report Attribute |
Details |
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Market size value in 2021 |
US$ 1.39 billion |
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Revenue forecast in 2030 |
US$ 3.98 billion |
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Growth Rate |
CAGR of 12.4% from 2022 to 2030 |
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Base year for estimation |
2021 |
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Forecast period |
2022-2030 |
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Historical Year |
2020 |
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Segments covered |
Type, Application, End-users, and Region. |
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Regional scope |
North America, Europe, Asia Pacific, and the Rest of the World (ROW) |
According to the deep-dive market assessment study by Growth+ Reports, the global human liver model market was valued at US$ 1.39 billion in 2021 and is expected to witness a CAGR of 12.4% during the forecast period from 2022 to 2030.
Market Fundamentals
The liver is a crucial organ that carries out several crucial body processes, including bile generation for digestion, protein synthesis, blood clotting factor synthesis, glucose storage in the form of glycogen, and detoxifying chemicals & metabolizing drugs. A human liver model is a structure used to examine the toxicity of a medicine that can lead to liver failure and other liver illnesses. It allows a better understanding of liver illness and the complicated spatial linkages of the liver's internal structure. Advanced liver models are mini-organs or organoids that are designed to mimic human liver physiology, architecture, and functions from the molecular layer up. The development of these live models is a novel field of study that has the potential to replace animal models. The human liver model is used to assess the toxicity of novel medications on the liver.
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Market Dynamics
Human liver modeling is a trending industry with high popularity among researchers & scientists and is expected to illustrate enormous growth during the projected period. Liver models are created by developing a virtual environment from single fetal progenitor liver cells. Continuous growth in the prevalence of diseases such as cancer and non-alcoholic fatty liver diseases and increased research into developing novel treatments are some of the key factors driving the demand for liver models. Liver disease is one of the major causes of death globally. Around 1.5 million annual deaths were reported in 2017 due to a lack of medical treatment and transplantable organs. The market growth can also be mostly ascribed to increased healthcare research & development (pre-clinical and clinical research), and breakthroughs in organ printing technology.
Additionally, the human liver models find application in various parts of the medical field, such as reducing the risk of drug-induced liver injury in humans, modeling human liver diseases, and enabling cell-based therapies in the clinic. It also has its application in elucidating the role of single and combinatorial microenvironmental cues on liver cell function. Moreover, growing emphasis on developing alternatives to animal-based models and accuracy in outcomes is also expected to drive market expansion. Furthermore, continuously growing competition amongst prominent players in the market is leading to their adoption of various growth strategies, such as the development & launch of new products and expanding & diversifying their market presence by acquiring a new client base. These overall factors encourage the growth of the human liver model market. However, the high cost of liver models and challenges with integrating liver models into current workflows are expected to hinder market expansion throughout the projected period.
Market Ecosystem
The global human liver model market has been analyzed from four perspectives: Type, Application, End-users, and Region.
Human Liver Model Market by Type
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The global human liver model market has been segmented based on type: liver organoids, animal models, liver-on-a-chip, 3D bioprinting, and 2D models. The liver-on-a-chip segment dominates the market with the largest share. Chips enable in vitro research of different processes and the development of liver disorders. They also play a key function in medication testing to suppress or cure them. Liver-on-a-chip systems provide much-needed cues like perfusion, shear stress, and three-dimensional (3-D) cell-cell contact, making them a viable alternative to traditional, static two-dimensional (2-D) cultures. Since the human liver is the metabolic center and plays a significant role in the effectiveness and clearance of systemic therapies, liver chips are of special interest in drug research.
Additionally, this system is one of the best alternatives to animal models, is modest, cost-effective, and can maintain metabolic activities similar to the in vivo environment, thus contributing to the growth of this segment, thereby boosting the overall market. The 3D bioprinting segment is also estimated to show considerable growth during the projected period. This 3D bioprinting technology enables and enhances the recapitulation of hepatocyte organization and cell-matrix contacts, the inclusion of additional cell types, the incorporation of fluid flow, and the creation of oxygen and nutrient gradients, resulting in improved differentiated cell phenotype and functionality. Thus, assisting the researchers in efficiently developing geometrically well-defined 3D scaffolds seeded with cells. Hence, encouraging the overall growth of the market.
Human Liver Model Market by Application
Based on the application, the global human liver model market has been classified into academics, drug discovery, and others. The drug discovery segment dominates the market with the largest share. The growth of this segment can be attributed to increasing cases of chronic diseases globally. Liver models play a crucial role in preclinical drug development and prove beneficial for drug testing. As conventional preclinical models are frequently restricted to a certain point and cannot detect drug toxicity, the dangers these treatments pose to humans can only be discovered in clinical trials. This results in a time-consuming and expensive procedure for the pharmaceutical industry to develop fallacious medications. For developing a potential drug, advanced technology such as human liver models (especially liver-on-chip) are used widely as these models can mimic organ-level pathophysiology with clinical response.
Human Liver Model Market by End-User
According to end-user, the global human liver model market is classified into research institutes & academics, pharmaceutical companies, and others. Pharmaceutical companies accounted for the largest revenue share in the global market. Rising incidences of various rare diseases among the population play a crucial role in the growth of this segment. The increasing prevalence of diseases boosts the need for an effective and enhanced medical solution for the treatment, thereby propelling the pharmaceutical segment growth. Additionally, in growing cases of chronic diseases and in oncology, the human liver model can greatly help develop novel treatments or therapy, hence encouraging the growth of the pharmaceutical segment.
The research institutes & academics segment is estimated to illustrate lucrative growth in the projected timeframe from 2022 to 2030. The growth of this segment can be ascribed to rapidly increasing research activities in the pharmaceuticals and diagnostics space.
Human Liver Model Market by Region
The global human liver model market has been segmented based on regions into North America, Europe, Asia Pacific, and the Rest of the World. North America registered the highest share in 2021 in the global market. The growth of the human liver model market in this region can be attributed to a large base of pharmaceutical and biopharmaceutical industries (Life science industries) with a high penetration of human organoid technologies. Additionally, rapidly growing cases of rare and chronic diseases among the population, hence a large need for novel and advanced treatment, bolster the market growth in this region. Furthermore, the presence of advanced healthcare infrastructure due to the high adoption of advanced technologies and large healthcare expenditure by the government also encourages the overall growth of North America’s human liver model market.
Competitive Landscape
The prominent players operating in the global human liver model market are:
Strategic Development
The global human liver model market is expected to be US$ 3.98 billion in 2030
The high cost of liver models and challenges with integrating liver models into current workflows are expected to hinder market expansion throughout the projected period.
The global human liver model market is expected to grow at a CAGR of 12.4% during the forecast period from 2022 to 2030
The global human liver model market was estimated to be US$ 1.39 billion in 2021
Prominent market players in the global anti-fungal market are CB Information Services Inc., Organovo Holding Inc., Mimetas BV, InSphero, BioIVT, Cellink (Bico Group), Kerafast Inc., Thermo Fisher Scientific Inc., and HìREL.
*Insights on financial performance are subject to the availability of information in the public domain
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Snehal Deshmukh
Principle Consultant
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