Number of pages: 100 | Report Format: PDF | Published date: March 03, 2023
Historical Years – 2021 | Base Year – 2022 | Forecasted Years – 2023-2031
According to the deep-dive market assessment study by Growth Plus Reports, the global HLA typing market was valued at US$ 1.3 billion in 2022 and is expected to register a revenue CAGR of 6.4% to reach US$ 2.27 billion by 2031.
HLA Typing Market Fundamentals
HLA, or human leukocyte antigen, typing procedure is a genetic test. HLA matching is another name for HLA typing, a next-generation sequencing-based test that aids in determining the best match for organ and bone marrow donors in allogeneic transplants. In cases of bone marrow or organ transplantation, there is a risk of rejection as a patient’s immune system may identify the transplanted cells as foreign invaders through HLA recognition. HLA matching is an established method for assessing the compatibility of tissue transplantation. All donors must undergo this examination regardless of whether they are donating organs from a deceased person, a relative, or someone else. Thus, a good match lessens the possibility of issues developing after the transplant. HLA typing has proven to be a useful and adaptable clinical technique, enabling more effective paternity testing, platelet transfusion, and renal transplantation and serving as a diagnostic test for ankylosing spondylitis. A family’s HLA type can reveal which members are most susceptible to hemochromatosis and juvenile-onset diabetes mellitus.
HLA Typing Market Dynamics
The rise in the adoption of unhealthy lifestyles, including smoking, inactivity, and some unhealthy food, is responsible for the increasing prevalence of chronic diseases. Organ failure can be caused by several chronic conditions, including diabetes, polycystic kidney disease, lupus, cirrhosis, coronary artery disease, cardiomyopathy, and heart failure. According to the World Health Organization (WHO) estimates, chronic disease-related fatalities are likely to account for 70% of all deaths and 56% of all disease burden by 2030. Around 100,000 individuals had sickle cell disease (SCD) in 2021, according to May 2022 CDC data. Additionally, 4.4 out of every 10,000 live births worldwide are affected by thalassemia annually, according to news-medical.net, updated in August 2022. Global acceptance of HLA testing for the detection of genetic illnesses is expected to rise due to the increasing cases of genetic diseases, propelling market revenue growth.
HLA typing is essential for determining the HLA compatibility between organ donors and recipients and is required for a successful organ transplant. Thus, the market for HLA typing is anticipated to be driven by the rising cases of chronic disorders. The market’s primary drivers of expansion are anticipated to be the rising need for organ transplantation and the widespread usage of HLA testing in pharmacogenetics. The number of transplantations has gone up over time. According to the Organ Procurement and Transplantation Network, over 41,354 organ transplantations were carried out alone in the United States in 2021, up by 5.9% from 2020. The organs receiving the most transplants in 2021 were the kidney (24,669), liver (9,236), and heart (3,817). Yet, the loss of potential subjects for HLA testing whenever anyone dies due to a dearth of organ donors.
Using HLA testing in many applications broadens its application and increases demand. For instance, in February 2022, the biotech company NEC Oncolmmunity AS released their research describing a technique to explain the HLA of tumors and test new alleles of the HLA, which can help with tailored cancer immunotherapy. The approach tested for HLA using NGS data. The company worked with Ultimovacs ASA to confirm the method from the blood of diverse donors using deep target sequencing of HLA. The HLA typing was perfect, making the verification successful.
The global HLA typing market faces several restraints such as the high cost of the testing procedures. Additionally, the lack of awareness about the importance of HLA typing in disease diagnosis and treatment is another challenge. However, technological advancements and increasing government initiatives to promote HLA typing are expected to create business opportunities in the market.
HLA Typing Market Ecosystem
The global HLA typing market has been analyzed from five perspectives: product, application, technique, end-user, and region.
HLA Typing Market by Product
Based on product, the global HLA typing market has been segmented into reagents & consumables, instruments, and software & services.
The reagents & consumables segment accounted for the largest revenue share in the global HLA typing market in 2022. The HLA reagents and consumables complement goods used to improve the precision and efficiency of diagnoses in various diagnostic test kits, including HLA typing. The healthcare, clinical, and pharmaceutical industries are the primary users of reagents, according to the 2021 annual report Thermo Fisher Scientific Inc. Players from complementary or related markets are likely to be drawn to the area due to its exponential expansion, allowing them to create resource synergies and increase profits. For instance, Genome Diagnostics BV (GenDx), a major participant in the HLA typing market with a significant presence in the United States and Europe, was acquired by Eurobio Scientific in August 2022.
HLA Typing Market by Application
Based on application, the global HLA typing market has been segmented into diagnosis and research. The diagnosis segment is sub-segmented into infectious disease, donor-recipient cross-matching, and cancer.
The diagnosis segment accounted for the largest revenue share in the global HLA typing market in 2022. It can identify conditions including rheumatoid arthritis, narcolepsy, and Behcet’s illness. These applications open the door for faster growth of the HLA matching industry.
HLA Typing Market by Technique
Based on technique, the global HLA typing market has been segmented into molecular assay and non-molecular assay.
The molecular assay segment accounted for the largest revenue share in the global HLA typing market in 2022. The most popular method for HLA typing uses molecular techniques such as massively parallel sequencing or hybridization methods based on probes. Many genetic techniques, including PCR followed by massively parallel sequencing, can be used for molecular typing. Different techniques are used depending on the donors and the organs to be transplanted. For instance, molecular class I and class II HLA loci are done for deceased donors, while high-resolution molecular class I HLA loci are advised for hematopoietic stem cell transplantation.
HLA Typing Market by End-user
Based on end-user, the global HLA typing market has been segmented into hospitals and transplant centers, research labs and academic institutes, and commercial service providers.
The hospitals and transplant centers segment accounted for the largest revenue share in the global HLA typing market in 2022. Around 147 hospitals and transplant centers in the United States perform liver transplants. Over 181 applicants received transplants from deceased donors and one from a living donor at Houston Methodist Hospital between January 2021 and December 2021. Comparable to Stanford Health Care, 103 and 164 transplants were completed within the same period at VCU Health System Authority, VCUMC. Thus, the demand for HLA typing is growing faster than the number of transplants in hospitals and transplant centers.
The rise in the HLA typing services offered by academic and research institutions is anticipated to positively impact the estimated value of the market. For instance, the University of Rochester Medical Center Rochester provides thorough services in cross-matching, HLA typing, and antibody testing at several degrees of resolution that can be tailored to the client’s needs. As a result, the need for service providers for drug sensitivity testing, transplantation programs, and eligibility screening for the vaccine has increased among these end-users. Rising hospital initiatives for running camps and bone marrow donation programs will also contribute to the market expansion. For instance, Aster Hospitals organized a stem-cell donor drive in May 2022 to raise awareness and give hope to children with thalassemia. This drive was organized with World Thalassemia Day and in partnership with I Love To Care (India) Charitable Trust and DKMS-BMST Foundation India. The program aimed to nudge people into signing up as stem cell donors. The market is expected to be fueled by such initiatives, which will expand the usage of HLA testing in hospitals to match patients’ bone marrow.
HLA Typing Market by Region
Based on region, the global HLA typing market has been segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa.
North America accounts for the largest revenue share in the global HLA typing market. This is driven by the growing prevalence of hereditary illnesses and government campaigns to raise public awareness. According to the NIH, in May 2022, funding for organ transplants in the United States was reported US$ 208 million in 2020 and USD 201 million in 2021, respectively. The substantial support by the United States for organ translation will increase the number of organ translations, growing the acceptance of HLA typing and fueling market revenue growth in this region. Moreover, the Organ Procurement and Transportation Network reported in January 2022 that about 41,354 organ transplants were performed in the United States in 2021, an increase of 5.9% from the year before and a first for breaking the 40,000 mark. Due to the high rate of organ transplants in industrialized nations, the market for HLA typing will see significant acceptance during the forecast period.
The increasing focus of leading regional market players on HLA product launches is anticipated to fuel market expansion in North America. For instance, Immucor introduced Mia Fora NGS Express HLA Typing Software in March 2022 to provide users of Mia Fora NGS MFlex HLA Typing assays with a quicker and simpler NGS analysis experience. Such HLA typing software will encourage greater HLA typing use, fueling market expansion in this region.
The market in Asia Pacific is projected to observe the fastest revenue growth during the forecast period. This is due to improved healthcare facility infrastructure, well-designed insurance policies, and economic growth factors. The presence of more transplant hospitals and competent workers, and laboratories with cutting-edge technology are expected to drive revenue growth in the regional market.
HLA Typing Market Competitive Landscape
The rise in the number of product launches by several biotechnological firms, the rise in innovative biotechnological companies, and the increase in genetic testing have led to a fragmentation of the HLA typing industry. In order to expand globally, businesses and service providers in the HLA matching industry are embracing strategies, such as technological developments and discoveries, vertical collaborations, product portfolio expansion, mergers and acquisitions, and regional expansions.
Some of the prominent players operating in the global HLA typing market are: -
HLA Typing Market Strategic Developments
The global HLA typing market is expected to grow at a revenue CAGR of 6.4% during the forecast period.
Asia Pacific accounts for the highest revenue growth rate in the global HLA typing market.
Bio-Rad Laboratories Inc., Thermo Fisher Scientific Inc., Omixon Inc., Qiagen N.V., and TBG Diagnostics Limited are among the key players in the global HLA typing market.
The increase in the prevalence of chronic diseases and the rise in demand for organ transplantations are major factors driving the global HLA typing market revenue growth.
The HLA typing market was valued at US$ 1.3 billion in 2022.
*Insights on financial performance are subject to the availability of information in the public domain