Number of pages: 100 | Report Format: PDF | Published date: February 08, 2023
Historical Years – 2020 | Base Year – 2021 | Forecasted Years – 2022-2030
According to the deep-dive market assessment study by Growth Plus Reports, the global antibody chips market was valued at US$ 7.0 billion in 2021 and is expected to register a revenue CAGR of 7.5% to reach US$ 13.42 billion by 2030.
Antibody Chips Market Fundamentals
An antibody chip (or protein chip) is a high-throughput technology for tracking the interactions and activities of proteins and establishing their function on a wide scale. Its key advantage is that it can track a large number of proteins at the same time. A glass slide, nitrocellulose membrane, bead, or microtiter plate serves as the chip's support surface, on which an array of capture proteins is coupled. Probe molecules are added to the array, which is commonly tagged with a fluorescent dye. Any interaction between the probe and the immobilized protein produces a fluorescent signal that a laser scanner can detect.
Protein microarrays are fast, automated, cost-effective, and highly sensitive, requiring only a small amount of sample and reagent. Protein microarrays were created in response to the limitations of utilizing DNA microarrays to determine gene expression levels in proteomics. The amount of mRNA in the cell frequently does not correlate to the amounts of protein expression. As it is normally the protein, not the mRNA, that plays the functional role in cell response, a unique strategy was required. The proteins are arranged in a grid on a solid surface, such as microscope slides, membranes, beads, or microtiter plates. This surface's function is to provide support for proteins to be immobilized. It should exhibit maximum binding qualities while keeping the protein in its native shape to retain binding ability. Glass or silicon microscope slides are a common choice as they are compatible with the easily obtained robotic arrears and laser scanners created for DNA microarray technology. Protein array detection methods must provide a high signal-to-noise ratio. Fluorescence labeling is the most commonly used approach for detection since it is sensitive, safe, and compatible with easily available microarray laser scanners. Other labels, such as affinity, photochemical, or radioisotope tags, can be utilized. These labels are applied to the probe and may disrupt the probe-target protein reaction.
Three types of protein microarrays are now utilized to examine protein biochemical activities: analytical microarrays, functional microarrays, and reverse-phase microarrays. Analytical microarrays are commonly used to profile a complex combination of proteins in order to determine binding affinities, specificities, and protein expression levels. A library of antibodies, aptamers, or affibodies is placed on a glass microscope slide in this procedure. Functional protein chips differ from analytical chips in that they contain arrays of full-length functional proteins or protein domains. In a single experiment, these protein chips are utilized to analyze the biochemical activities of a whole proteome. They are used to investigate a wide range of protein interactions, including protein-protein, protein-DNA, protein-RNA, protein-phospholipid, and protein-small molecule interactions.
Antibody Chips Market Dynamics
Antibody chips are frequently employed in basic research in healthcare and biomedical companies. Furthermore, these chips have been used in drug development research initiatives involving infectious and fatal disorders. Protein chips are comprised of a support surface, such as a glass slide or microtiter plate, that aids in capturing protein in use, and these molecules are then labeled and assembled in a dye of a certain color and added to the array. Any interaction between them is then signaled and recorded for future experimentation.
The expanding demand for personalized medications and increasing adoption of target-specific pharmaceuticals are major drivers for the antibody chips market. Most large pharmaceutical companies have made significant investments in R&D projects and have implemented cutting-edge microarray technologies. These efforts are expected to fuel revenue growth in the market during the forecast period. Furthermore, the flourishing biomedical and biotechnology industries are expected to contribute to an increase in demand for protein chips. The trend is expected to help the global antibody chips market grow the fastest, particularly in Asia Pacific, owing to the rising population, increasing number of infectious diseases, growing technological advancements, and growing awareness about target-oriented drug delivery therapies for cancer treatment in this region.
Antibody Chips Market Ecosystem
The global antibody chips market has been analyzed from three perspectives: technology, end user, and region.
Antibody Chips Market by Technology
Based on technology, the global antibody chips market has been segmented into analytical microarrays, functional protein microarrays, and reverse-phase protein microarrays.
The analytical microarrays segment is expected to dominate the market during the forecast period. Analytical microarrays are commonly used to profile a complex combination of proteins in order to determine binding affinities, specificities, and protein expression levels. A library of antibodies, aptamers, or affibodies is placed on a glass microscope slide in this procedure. A protein solution is then used to probe the array. The most frequent type of analytical microarray is an antibody microarray. These microarrays can be used to track differential expression profiles as well as for clinical diagnosis. Profiling responses to environmental stress and healthy vs. sick tissues are two examples. On the contrary, functional protein microarrays differ from analytical arrays in that they are made up of arrays that contain full-length functional proteins or protein domains.
Antibody Chips Market by End User
Based on end user, the global antibody chips market has been segmented into hospitals & clinic, diagnostic laboratories, academic & research institutes, and pharmaceutical & biotechnological companies.
The academic & research institutes segment is expected to dominate the market during the forecast period. This is due to the increased research and development activities in proteomics. Proteomics is the study of protein function, structure, expression, interaction, and alteration in pathological and physiological states. Protein chips are a significant area of interest in the study of proteomics. One of the key goals of the researchers is to create a complete relational database for metabolic and signal transduction pathways utilizing a protein chip in the future.
Antibody Chips Market by Region
Based on region, the global antibody chips market has been segmented into North America, Europe, Asia Pacific, Rest of the Word.
North America is likely to dominate the global antibody chips market during the forecast period, owing to well-established protein chip laboratories and research institutions that developed the world’s first microarray chip for complete protein analysis. The innovative protein chip has the potential to significantly advance research into protein function in creatures other than yeast, such as humans. The majority of development occurs through protein interactions, and illnesses can emerge if proteins do not interact appropriately. This method helps healthcare providers and academics to understand the function of different proteins considerably faster than current methods. This is likely to open up new prospects for businesses and researchers.
Asia Pacific is projected to be the fastest-growing region in the market during the forecast period, owing to an increase in demand for protein microarray assays, growth in awareness, and rise in research and development efforts in the region's countries. For instance, Toray Industries, headquartered in Japan, developed the new Frontiers Research Laboratories with the purpose of supporting advanced fundamental research in biotechnology and nanotechnology.
Antibody Chips Market Competitive Landscape
The prominent market players in the global antibody chips market include:
Antibody Chips Market Strategic Developments
Asia Pacific is the key revenue growth region in the global antibody chips market.
The increase in research and development activities, the rising prevalence of ailments, and the improved quality of healthcare facilities are the prime factors fueling revenue growth in the market.
The global antibody chips market is expected to be valued at US$ 13.42 billion by 2030.
The global antibody chips market is expected to register a revenue CAGR of 7.5% during the forecast period from 2022 to 2030.
Agilent Technologies Inc., Bio-Rad Laboratories, Inc., Raybiotech Inc, DANAHER CORPORATION, and Illumina, Inc. are among the leading players in the global market.
*Insights on financial performance are subject to availability of the information in the public domain