Antibody Chips Market

Report Overview

According to the deep-dive market assessment study by Growth+ Reports, the global antibody chips market was valued at US$ 7.0 billion in 2021 and is expected to witness a CAGR of 7.5% during the forecast period.

Market Fundamental 

An antibody chip (or protein chip) is a high-throughput technology for tracking the interactions and activities of proteins and establishing their function on a wide scale. Its key advantage is that it can track a large number of proteins at the same time. A glass slide, nitrocellulose membrane, bead, or microtitre plate serves as the chip's support surface, on which an array of capture proteins is coupled. Probe molecules are added to the array, which are commonly tagged with a fluorescent dye. Any interaction between the probe and the immobilised protein produces a fluorescent signal that a laser scanner can detect. Protein microarrays are fast, automated, cost-effective, and highly sensitive, requiring only a little amount of sample and reagent. Protein microarrays were created in response to the limitations of utilising DNA microarrays to determine gene expression levels in proteomics. The amount of mRNA in the cell frequently does not correlate to the amounts of protein expression. Because it is normally the protein, not the mRNA, that plays the functional role in cell response, a unique strategy was required. The proteins are arranged in a grid on a solid surface, such as microscope slides, membranes, beads, or microtitre plates. This surface's function is to provide a support for proteins to be immobilised on. It should exhibit maximum binding qualities while keeping the protein in its native shape to retain binding ability. Glass or silicon microscope slides are a common choice because they are compatible with the easily obtained robotic arrayers and laser scanners created for DNA microarray technology. Protein array detection methods must provide a high signal to noise ratio. Fluorescence labelling is the most frequent and commonly used approach for detection since it is sensitive, safe, and compatible with easily available microarray laser scanners. Other labels, such as affinity, photochemical, or radioisotope tags, can be utilised. These labels are applied to the probe and may disrupt the probe-target protein reaction. Protein microarrays of three types are now utilised to examine protein biochemical activities: analytical microarrays, functional microarrays, and reverse phase microarrays. Analytical microarrays are commonly used to profile a complex combination of proteins in order to determine binding affinities, specificities, and protein expression levels. A library of antibodies, aptamers, or affibodies is placed on a glass microscope slide in this procedure. Functional protein chips differ from analytical chips in that they contain arrays of full-length functional proteins or protein domains. In a single experiment, these protein chips are utilised to analyse the biochemical activities of a whole proteome. They are used to investigate a wide range of protein interactions, including protein-protein, protein-DNA, protein-RNA, protein-phospholipid, and protein-small molecule interactions.

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Market Dynamics

Antibody chips are frequently employed in basic research in healthcare and biomedical companies. Furthermore, these chips have been used in drug development research initiatives involving infectious and fatal disorders. Protein chips are made comprised of a support surface, such as a glass slide or micro titre plate, that aids in the capture of protein in use, and these molecules are then labelled and assembled in a dye of a certain colour and added to the array. Any interaction between them is then signalled and recorded for future experimentation. The expanding demand for personalised medications, as well as the increasing demand for target specific pharmaceuticals, are major drivers for the antibody chip market. Most large pharmaceutical companies have made significant investments in R&D and have implemented cutting-edge microarray technology. This is being studied in order to help the market develop even further. Furthermore, the flourishing biomedical and biotechnology industries will contribute to an increase in market demand for protein chips. As a result, this trend is expected to help the global antibody chips market grow the fastest, particularly in the APAC region, owing to rising population, rising number of infectious diseases, increasing technological advancements, and rising awareness about target-oriented drug delivery therapies for cancer treatment.

Market Ecosystem 

The global antibody chips market has been analysed from three perspectives by technology, end user and region. 

Antibody Chip Market by Technology

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Based on technology, the global antibody chips market has been segmented into analytical microarrays, functional protein microarrays, and reverse phase protein microarrays. The analytical microarrays dominated the market during forecast period. Analytical microarrays are commonly used to profile a complex combination of proteins in order to determine binding affinities, specificities, and protein expression levels. A library of antibodies, aptamers, or affibodies is placed on a glass microscope slide in this procedure. A protein solution is then used to probe the array. The most frequent type of analytical microarray is an antibody microarray. These microarrays can be used to track differential expression profiles as well as for clinical diagnosis. Profiling responses to environmental stress and healthy vs sick tissues are two examples. On contrary, Functional protein microarrays differ from analytical arrays in that they are made up of arrays that contain full-length functional proteins or protein domains. In a single experiment, these protein chips are utilised to analyse the biochemical activities of a whole proteome. They are used to investigate a wide range of protein interactions, including protein-protein, protein-DNA, protein-RNA, protein-phospholipid, and protein-small molecule interactions.

Antibody Chip Market by End User 

Based on end user, the global antibody chips market has been segmented into hospitals & clinic, diagnostic laboratories, academic & research institutes, pharmaceutical & biotechnological companies. The academic & research institutes dominated the market during forecast period. This is due to the increased research and development activity in proteomics. The study of protein function, structure, expression, interaction, and alteration in pathological and physiological states is referred to as proteomics. Protein chips are a significant area of interest in the study of proteomics. One of the key goals of the researchers is to create a complete relational database for metabolic and signal transduction pathways utilising a protein chip in the future.

Antibody Chip Market by Region 

Based on region, the global antibody chips market has been segmented into North America, Europe, Asia Pacific, Rest of the Word. North America is likely to dominate the worldwide antibody chips market during the forecast period, owing to well-established protein chip laboratories and research institutions that developed the world's first microarray chip for complete protein analysis. The innovative protein chip has the potential to significantly advance research into protein function in creatures other than yeast, including humans. The majority of development occurs through protein interactions, and illnesses can emerge if proteins do not interact appropriately. This method helps healthcare providers and academics to understand the function of different proteins considerably faster than current methods. This is likely to open up new prospects for businesses and researchers.

The Asia Pacific region is predicted to be the fastest growing region during the forecast period, owing to an increase in demand for protein microarray assays, increased awareness, and increased research and development efforts in the region's countries. For example, Toray Industries, headquartered in Japan, developed the new Frontiers Research Laboratories with the purpose of supporting advanced fundamental research in biotechnology and nanotechnology.

Competitive Landscape 

Some of the prominent market players in the global antibody chips market include:

• Agilent Technologies Inc.        
• Bio-Rad Laboratories, Inc.
• Raybiotech Inc
• DANAHER CORPORATION      
• Illumina, Inc.   
• Microarrays Inc.
• Arrayit Corporation     
• PerkinElmer Inc.          
• QUOTIENT LIMITED
• Merck & Co., Inc.        
• Thermo Fisher Scientific, Inc.  

Strategic Development 

• In March 2022, Sengenics has released the i-Ome Protein Array Kit. The i-Ome Protein Array Kit contains 1600+ immobilised, fully expanded, correctly folded human proteins on slide-based protein microarrays.
• In April 2020, China developed a SARS-CoV-2 proteome microarray that contained 18 of the 28 expected proteins and was used to analyse IgG and IgM antibody responses in 29 convalescent patients. These responses provide information that can be used to develop more effective diagnostic, therapeutic, and vaccination strategies.
• In October 2022, Senator Chris Murphy of Connecticut named Quantum- Si the "Innovator of the Month" for October. Quantum- Si, a life science startup, has created a next generation, single- molecule protein sequencing technique to expand drug development and diagnostics beyond what DNA sequencing has enabled. This technology is driven by the world's first semiconductor chip. 
• In August 2022, Proteintech Genomics, a new subsidiary corporation under the ownership of Proteintech Genomics, is creating entirely optimised and highly multiplex proteomic assays in the burgeoning life sciences city of San Diego, California. The goal is to spread the potential of multi-omics throughout the research community.

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